LEPTIN A19G POLYMORPHISM AND LEPTIN RECEPTOR Gln223Arg AND Lys109Arg POLYMORPHISMSIN POSTMENOPAUSAL OSTEOPOROSIS
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چکیده
منابع مشابه
Leptin receptor polymorphism Gln223Arg (rs1137101) in oral squamous cell carcinoma and potentially malignant oral lesions
The purpose of this study was to assess the LEPR gene Gln223Arg polymorphism (rs1137101) in oral squamous cell carcinoma (OSCC) and in potentially malignant oral lesions (PMOL) in comparison to normal oral mucosa in a Brazilian population. Smokers (n = 89) were selected from a representative sample of 471 individuals from the general population of Montes Claros, Brazil. Participants were age an...
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Objective(s):Leptin receptor (LEPR) is a member of the class I cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. We have investigated the effect of Q223R polymorphism on the breast cancer susceptibly in a sample of Iranian subjects. Materials and Methods:We utilized a polymerase chain reaction (PCR) restriction fragment length polymorphi...
متن کاملImpact of Leptin Receptor Gene GLN223ARG Polymorphism on Obesity in Jeddah City
Obesity is a major global epidemic problem. Obesity results from the combined effects of genes, environment, lifestyle and the interactions of these factors. The leptin receptor gene plays a critical role in the regulation of body weight. Genetic variations of leptin receptor gene may play a role in the pathophysiology of human obesity. In this study, the association between the LepR gene polym...
متن کاملRelationships between plasma leptin levels, leptin G2548A, leptin receptor Gln223Arg polymorphisms and gestational diabetes mellitus in Chinese population
The purposes of this study were to examine concentrations of leptin and biochemical parameters in gestational diabetes mellitus (GDM) patients and normal glucose tolerance (NGT) individuals, and also to explore the links of leptin (LEP) G2548A and leptin receptor (LEPR) Gln223Arg polymorphisms with leptin levels and GDM risk among Chinese. Our study included 357 GDM and 355 NGT individuals who ...
متن کاملBone mass regulation of leptin and postmenopausal osteoporosis with obesity.
BACKGROUND Leptin has been known to play a role in weight regulation through food intake and energy expenditure. Leptin also has an important role in bone metabolism. The role of leptin is determined by leptin receptors, either central or peripheral to the bones. DESIGN We discuss the role of leptin on bone and molecular genetics of osteoporosis in postmenopausal obese women. RESULTS The ro...
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ژورنال
عنوان ژورنال: Rheumatology Science and Practice
سال: 2010
ISSN: 1995-4492,1995-4484
DOI: 10.14412/1995-4484-2010-727